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Effect of chronic amitriptyline administration on serotonergic receptors in rats with methylazoxymethanol-induced
M Watanabe1, Y Kodama, Y Hagino
1Department of Psychopharmacology, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156, Japan. watanabe@prit.go.jp
Brain Research
|May 21, 1998
Abstract:
Methylazoxymethanol (MAM)-induced cortical hypoplasia resulted in a 20% decrease in the Bmax of 5-HT2A receptors in the frontal cortex with no change in the Bmax of 5-HT1A receptors. Chronic treatment with amitriptyline did not further decrease the Bmax of 5-HT2A receptors in the MAM-lesioned cortex, suggesting that the persistent down-regulation of cortical 5-HT2A receptors in MAM-lesioned rats was induced by serotonergic hyperinnervation.
