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Novel site-specific DNA endonucleases
1Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA. Aggarwal@inka.mssm.edu
Current Opinion in Structural Biology
|March 31, 1998
Abstract:
Site-specific hydrolysis of DNA is common to many biological processes. Three new structures, FokI, I-CreI and PI-SceI, were reported in the past year, providing the first view of type IIs endonucleases and homing endonucleases. Together, they reveal an extraordinary set of new mechanisms by which endonucleases target the hydrolysis of specific DNA sequences.