Related Experiment Video
Updated: Aug 19, 2026
Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
Lymph node metastasis in patients with carcinomas of the renal pelvis and ureter
N Miyao1, N Masumori, A Takahashi
1Department of Urology, Sapporo Medical University School of Medicine, Japan.
Objectives:
We evaluated the clinical significance of lymph node metastasis in patients with carcinomas of the renal pelvis and ureter.
Methods:
68 patients without distant metastasis were included in this study. Multivariate analysis by Cox's proportional hazards model was applied to detect the prognostic factor(s).
Results:
12 patients (17.6%) had nodal involvement. More than 10% of the patients with pT1-2 showed nodal metastasis. Preoperatively determined clinical factors were not a predictive factor for nodal involvement. Nodal metastasis was the only significant negative prognostic factor for patient survival by multivariate analysis.
Conclusions:
Lymph node dissection is valuable to predict the clinical outcome of the patients with carcinoma of the renal pelvis and ureter. Attention should be paid to nodal status to select patients for conservative surgery.
Related Concept Videos
02:30Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations