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Measurement standards for strontium-89 for use in bone palliation
B M Coursey1, F J Schima, D B Golas
1Ionizing Radiation Division, National Institutes of Standards and Technology, Department of Commerce, Gaithersburg, MD 20899, USA.
Summary
High-purity Strontium-89 (89Sr) standards were developed for accurate instrument calibration. These standards ensure reliable measurements from production to clinical use, improving radiopharmaceutical quality control.
Area of Science:
- Nuclear chemistry
- Radiopharmaceutical science
- Metrology
Background:
- Accurate calibration of instruments is crucial for the reliable measurement of radionuclides.
- Strontium-89 (89Sr) is used in nuclear medicine and requires precise quantification.
- Existing 89Sr standards may have impurities affecting measurement accuracy.
Purpose of the Study:
- To prepare high-purity Strontium-89 (89Sr) standards for instrument calibration.
- To evaluate different reactor production schemes for optimal 89Sr yield and purity.
- To establish a reliable Standard Reference Material (SRM) for 89Sr.
Main Methods:
- Evaluation of alternative reactor production methods to minimize 85Sr impurities.
- Purification techniques to remove unwanted radionuclidic impurities.
- Standardization using high-efficiency liquid-scintillation counting.
Main Results:
- High-purity 89Sr was successfully produced with minimal 85Sr impurity.
- The prepared 89Sr standards achieved a relative expanded uncertainty of 0.48%.
- A Standard Reference Material (SRM 4426A) was established and distributed.
Conclusions:
- The developed 89Sr standards are suitable for calibrating various measurement instruments.
- These standards enhance the accuracy of 89Sr measurements in clinical and radiopharmaceutical settings.
- The SRM 4426A provides a reliable basis for quality assurance in 89Sr applications.