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Related Experiment Videos

Reduction in voice tremor under thalamic stimulation

M A Carpenter1, R Pahwa, K L Miyawaki

  • 1Hearing and Speech Department, University of Kansas Medical Center, Kansas City 66160-7605, USA.

Neurology
|April 1, 1998
PubMed
Summary
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Deep brain stimulation (DBS) of the ventral intermediate thalamic nucleus may improve voice tremor in some essential tremor patients. Benefits were observed in patients with more severe voice symptoms, suggesting an additional therapeutic advantage.

Area of Science:

  • Neurology
  • Neurosurgery

Background:

  • Essential tremor (ET) is a common neurological disorder.
  • Deep brain stimulation (DBS) is an established treatment for managing hand tremor in ET.
  • Voice symptoms can also occur in ET patients, impacting quality of life.

Purpose of the Study:

  • To investigate the effect of DBS targeting the ventral intermediate thalamic nucleus on voice symptoms in patients with essential tremor.
  • To assess whether DBS for hand tremor provides concurrent benefits for voice tremor.

Main Methods:

  • Seven patients with essential tremor who had undergone DBS for hand tremor were studied.
  • Voice tremor was evaluated with and without thalamic stimulation using patient and clinician severity ratings, and acoustic measures (rate and amplitude).
  • Patients had received either unilateral or bilateral DBS implants.

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Main Results:

  • Four out of seven patients demonstrated reductions in voice symptoms with DBS.
  • Improvements in voice tremor were observed in at least two evaluation measures for these patients.
  • Observed voice gains were typically associated with more severe initial voice symptoms and did not directly correlate with upper extremity tremor improvement.

Conclusions:

  • Deep brain stimulation of the ventral intermediate thalamic nucleus may offer a potential benefit for voice tremor in select essential tremor patients.
  • Reduced voice tremor can be an additional, albeit not universal, advantage of DBS therapy for essential tremor.
  • Further research is warranted to identify predictors for voice symptom improvement with DBS.