Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Traumatic neuropathology

G S Pearl1

  • 1Department of Pathology, Orlando Regional Healthcare System, Florida, USA.

Clinics in Laboratory Medicine
|April 2, 1998
PubMed
Summary
This summary is machine-generated.

This review categorizes traumatic brain injury neuropathology into primary and secondary mechanisms. Understanding these injury types, including impact, inertial, and secondary effects, is crucial for diagnosis and treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proximal myotonic myopathy: clinical, neuropathologic, and molecular genetic features.

Annals of clinical and laboratory science·2001
Same author

Lipofibromatous hamartoma and related peripheral nerve lesions.

Southern medical journal·2000
Same author

Adrenoleukodystrophy: unusual clinical and radiographic manifestation.

Southern medical journal·1998
Same author

Fatal rhino-orbital-cerebral zygomycosis.

Southern medical journal·1997
Same author

Diagnosis of Alzheimer's disease in a community hospital-based brain bank program.

Southern medical journal·1997
Same author

Continuous quality improvement (CQI) in neuropathology.

Journal of neuropathology and experimental neurology·1996
Same journal

Advances in Hemostasis Laboratory Testing.

Clinics in laboratory medicine·2026
Same journal

Extracellular Vesicles in Hemostasis.

Clinics in laboratory medicine·2026
Same journal

Thrombin Generation Assay: Ready for Prime Time.

Clinics in laboratory medicine·2026
Same journal

Viscoelastic Testing for the Laboratorian: Recent Advances and Practical Advice.

Clinics in laboratory medicine·2026
Same journal

Practical Recommendations for Harmonization of Hemostasis Testing Across Hospital Sites.

Clinics in laboratory medicine·2026
Same journal

The Role of Hypoxia in Vascular Endothelial Dysfunction and Venous Thromboembolism.

Clinics in laboratory medicine·2026
See all related articles

Area of Science:

  • Neuropathology
  • Trauma research
  • Neuroscience

Background:

  • Traumatic brain injury (TBI) encompasses a range of pathologies resulting from external forces.
  • Understanding the temporal and mechanistic aspects of TBI is critical for effective clinical management.
  • Existing literature often categorizes TBI based on injury timing and biomechanical forces.

Purpose of the Study:

  • To provide a comprehensive review of the neuropathology of trauma.
  • To classify traumatic brain injuries based on the mechanism and timing of injury.
  • To elucidate the specific pathological features of primary impact, primary inertial, and secondary injuries, including those related to child abuse.

Main Methods:

  • Review of existing literature on traumatic brain injury neuropathology.

Related Experiment Videos

  • Classification of injuries into primary (immediate) and secondary (delayed) categories.
  • Categorization of primary injuries by impact or inertial mechanisms.

    • Main Results:

    • Primary impact injuries include skull fractures, epidural hematomas, brain contusions, lacerations, and intracerebral hemorrhages.
    • Primary inertial injuries encompass subdural hematomas, diffuse axonal injury, and diffuse vascular injury.
    • Secondary injuries result from complications such as hypoxia/ischemia, brain swelling, infection, and increased intracranial pressure.

    Conclusions:

    • Neuropathology of trauma can be systematically classified by injury mechanism and time.
    • Distinguishing between primary and secondary injury mechanisms is essential for understanding TBI progression.
    • This classification framework aids in the study and treatment of TBI, including cases of child abuse.