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Related Experiment Videos

Axillary hyperhidrosis: treatment with botulinum toxin A

I R Odderson1

  • 1Department of Rehabilitation Medicine, University of Washington, Seattle, USA.

Archives of Physical Medicine and Rehabilitation
|April 2, 1998
PubMed
Summary

Botulinum toxin type A effectively treated excessive underarm sweating (hyperhidrosis) in two men. Patients experienced significant sweating reduction within days, showing this neurotoxin as a viable treatment option.

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Hyperhidrosis treated by botulinum A exotoxin.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·1998

Area of Science:

  • Dermatology
  • Neurology

Background:

  • Hyperhidrosis is a condition causing excessive sweating, leading to significant emotional and social distress.
  • Effective treatments for hyperhidrosis are limited, necessitating novel therapeutic approaches.

Observation:

  • Two male patients with lifelong excessive axillary sweating were treated with botulinum toxin type A.
  • Injections were administered bilaterally to the axillary regions using 100 units of the toxin.

Findings:

  • Patients reported a cessation of excessive sweating within five days post-injection.
  • Quantitative measurements showed an average reduction of 71% and 76% in resting axillary sweating.
  • One patient experienced a 96% reduction in sweating during mental stress, with no reported complications.

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Implications:

  • Botulinum toxin A (chemodenervation) offers a safe and effective treatment for axillary hyperhidrosis.
  • This study quantifies the efficacy of botulinum toxin in reducing excessive underarm sweating.
  • Further research can explore long-term outcomes and broader applications of botulinum toxin for hyperhidrosis.