Related Experiment Video
Updated: Aug 13, 2026
Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery
Published on: March 4, 2021
Subretinal perfluorodecalin toxicity
G A Lee1, S J Finnegan, R D Bourke
1Royal Brisbane Hospital, Herston, Queensland, Australia.
Background:
Subretinal injection of perfluorocarbon liquids (PFCL) can occur during vitreoretinal surgery. The long-term effects of this complication are not well established.
Methods:
A case report is presented of a patient with retained subretinal perfluorodecalin following retinal detachment repair for a giant retinal tear.
Results:
In the early postoperative period, the macular retinal pigment epithelium (RPE) became opalescent in appearance and by 2 months postoperatively the patient developed macular RPE atrophy with resulting poor central vision.
Conclusions:
Toxicity of subretinal perfluorodecalin causing RPE atrophy is proposed. We recommend all traces of PFCL should be removed if possible.
