[Proarrhythmia--a paradox in clinical cardiology]

On the basis of both literature data and our own experience, the review analyzes the problem of proarrhythmia. The origin of proarrhythmia is determined by: left ventricular function, coronary bloodflow, autonomous nervous system tonus, the presence of hidden lesions of the conductive system of the heart or the presence of accessory tracts, antiarrhythmic therapy or other therapy with cardiotropic preparations and the state of the internal environment. Each antiarrhythmic drug can evoke proarrhythmia. Regarding the therapy of current proarrhythmia, the competitive preference is ascribed to those antiarrhythmic drugs which are quickly eliminated. Regarding both the antiarrhythmic therapy and the possible occurrence of proarrhythmia in patients with ichaemic heart disease, the administration of Beta-blockers seems to be mostly prospective. (Fig. 3, Ref. 11).