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Related Experiment Videos

Pet sensitivities in asthmatic children

J K Sarsfield, A G Boyle, E M Rowell

    Archives of Disease in Childhood
    |March 1, 1976
    PubMed
    Summary

    Large skin test reactions in asthmatic children can indicate clinically significant animal allergies. Further investigation is needed due to limitations in current diagnostic animal extracts.

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    Area of Science:

    • Pediatric Allergy and Immunology
    • Environmental Health

    Background:

    • Asthma is a common chronic respiratory disease in children.
    • Identifying specific allergens is crucial for effective asthma management.
    • Pet ownership is prevalent, raising concerns about animal-induced asthma.

    Purpose of the Study:

    • To investigate the relationship between pet contact, clinical sensitivity, and objective allergy markers in asthmatic children.
    • To evaluate the diagnostic utility of skin prick tests and specific IgE levels for animal allergies.
    • To explore potential exposure routes to animal allergens in school environments.

    Main Methods:

    • A cohort of 118 asthmatic children was assessed for pet contact history and clinical sensitivity.
    • Skin prick testing and radioallergosorbent testing (RAST) for specific IgE were performed.
    • A questionnaire survey identified potential animal allergen exposure in day schools.

    Main Results:

    • A history of pet contact or clinical sensitivity was reported in 55% of children.
    • Children with apparent clinical sensitivity showed larger skin test reactions and higher specific IgE levels.
    • Positive skin tests were common (80%), with larger reactions (weal > 4mm) correlating with positive history or IgE.
    • Commercial animal extracts demonstrated diagnostic limitations.

    Conclusions:

    • Large skin test reactions are valuable indicators of clinically relevant animal allergies in asthmatic children.
    • Current commercial animal allergen extracts may have limitations for accurate diagnosis.
    • Schools represent a significant environment for potential exposure to animal allergens.

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