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Reversible intestinal mucosal abnormality in acrodermatitis enteropathica
Archives of Disease in Childhood
|March 1, 1976
Summary
Acrodermatitis enteropathica treatment improved intestinal mucosa abnormalities. Oral zinc therapy effectively restored normal cellular and villous patterns, unlike di-iodohydroxyquinoline.
Area of Science:
- Gastroenterology
- Pediatrics
- Dermatology
Background:
- Acrodermatitis enteropathica (AE) is a rare genetic disorder of zinc malabsorption.
- Intestinal mucosal abnormalities are observed in patients with AE.
Observation:
- Duodenal biopsies in three AE cases revealed intestinal mucosa abnormalities at the start of treatment.
- Biopsies during treatment showed progressive mucosal improvement.
Findings:
- Oral zinc sulfate therapy led to complete restoration of normal intestinal cellular and villous patterns.
- Di-iodohydroxyquinoline therapy showed less efficacy in normalizing intestinal epithelial cells and lamina propria inflammation compared to zinc.
Implications:
- This study highlights the critical role of zinc in maintaining intestinal mucosal integrity in AE.
- Effective zinc supplementation can reverse intestinal pathology in acrodermatitis enteropathica.
- Findings support zinc as a primary therapeutic agent for AE-related gastrointestinal manifestations.