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Induction of mucosal B-cell memory by intramuscular inoculation of mice with rotavirus
1Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, and The University of Pennsylvania School of Medicine, 19104, USA. coffin@email.chop.edu
Journal of Virology
|April 3, 1998
Abstract:
We investigated the capacity of intramuscular (i.m.) immunization with heterologous-host rotavirus (simian strain RRV) to induce mucosal virus-specific memory B cells in mice. We found that prior i.m. immunization enhanced the magnitude of mucosal virus-specific immunoglobulin A (IgA) production but did not alter the site and timing of induction of virus-specific IgA responses after challenge.