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Bioactive amides of fatty acids

V V Bezuglov1, Bobrov MYu, A V Archakov

  • 1Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. vvbez@oxylipin.siobc.ras.ru

Biochemistry. Biokhimiia
|April 4, 1998
PubMed
Summary

Fatty acid amides are endogenous lipid bioregulators. These compounds, including ethanolamides, interact with cannabinoid receptors and exhibit cannabimimetic properties, influencing physiological processes like sleep and blood vessel formation.

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Area of Science:

  • Biochemistry
  • Lipid Metabolism
  • Neuropharmacology

Background:

  • Fatty acid amides are endogenous lipid bioregulators.
  • Ethanolamides are well-studied, with biosynthesis involving N-acylated phosphatidylethanolamines.
  • These compounds act as endogenous ligands for cannabinoid receptors (CB1 and CB2).

Purpose of the Study:

  • To review the biosynthesis and function of fatty acid amides.
  • To highlight the role of ethanolamides as endogenous cannabinoid receptor ligands.
  • To introduce novel fatty acid amide bioregulators.

Main Methods:

  • Literature review of fatty acid amide biosynthesis and function.
  • Analysis of biochemical pathways including amidation and phospholipase D hydrolysis.

Related Experiment Videos

  • Pharmacological assessment of cannabinoid receptor interactions.

    • Main Results:

    • Fatty acid amides are formed from fatty acids and amines.
    • Ethanolamides bind to CB1 and CB2 receptors, exhibiting cannabimimetic effects.
    • Simple amides like oleamide and erucamide act as sleep-inducing and angiogenic factors, respectively.
    • New bioregulators include amides of fatty acids with dopamine, serotonin, and vanillinamine.

    Conclusions:

    • Fatty acid amides represent a diverse class of endogenous lipid bioregulators.
    • Ethanolamides are key endogenous ligands for cannabinoid receptors.
    • Fatty acid amides play significant roles in various physiological processes, with potential therapeutic implications.