Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia01:30

Dementia

487
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
487
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

764
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
764
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

1.7K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.7K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

945
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
945
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

973
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
973

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Community-based TB testing as an essential part of TB recovery plans in the COVID-19 era.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2021
Same author

Hypertension as a predictor of advanced colorectal cancer outcome and cetuximab treatment response.

Current oncology (Toronto, Ont.)·2019
Same author

[The importance of neuropsychological assessment for forensic psychiatric evaluations of defendants].

Tijdschrift voor psychiatrie·2016
Same author

Knowledge, attitudes and practices towards blood donation in Barbados.

Transfusion medicine (Oxford, England)·2016
Same author

Reciprocating instruments in endodontics: a review of the literature.

SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging·2015
Same author

Factors influencing the life span of modern root canal instruments--a literature review.

SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging·2013
Same journal

Tijdschrift voor gerontologie en geriatrie·2026
Same journal

[Peer-advice for aging in place: An exploratory study on the perspectives of community-dwelling older adults].

Tijdschrift voor gerontologie en geriatrie·2026
Same journal

[The Clinical Applicability of Blood Biomarkers for Alzheimer's disease in the Memory Clinic].

Tijdschrift voor gerontologie en geriatrie·2026
Same journal

[Geriatric rehabilitation on Curacao].

Tijdschrift voor gerontologie en geriatrie·2025
Same journal

[Usability of activity trackers in geriatric rehabilitation].

Tijdschrift voor gerontologie en geriatrie·2025
Same journal

[Frontotemporal dementia in the elderly: Practical tools].

Tijdschrift voor gerontologie en geriatrie·2025
See all related articles

Related Experiment Video

Updated: Jan 10, 2026

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K

[Dementia. Outlook on current developments]

C Jonker1

  • 1Vakgroep Psychiatrie, Vrije Universiteit Amsterdam.

Tijdschrift Voor Gerontologie En Geriatrie
|August 1, 1997
PubMed
Summary
This summary is machine-generated.

Recent studies refine dementia classification, distinguishing new entities like Lewy Body Dementia and Frontal Lobe Dementia. The amyloid cascade hypothesis offers a unified view for Alzheimer's disease pathogenesis and therapeutic development.

More Related Videos

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.1K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.2K

Related Experiment Videos

Last Updated: Jan 10, 2026

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.1K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.2K

Area of Science:

  • Neuropathology
  • Genetics
  • Neurobiology

Context:

  • Renewed interest in dementia syndrome differentiation based on neuropathologic and genetic studies.
  • Distinction of new disease entities: Lewy Body Dementia, Frontal Lobe Dementia.
  • Revised diagnostic criteria for vascular dementia, emphasizing CT/MRI evidence over Hachinski's Ischemic Score.

Purpose:

  • To explore differentiations within the dementia syndrome.
  • To evaluate the amyloid cascade hypothesis for Alzheimer's disease pathogenesis.
  • To highlight the importance of distinguishing cortical vs. subcortical dementia and early-onset vs. late-onset Alzheimer's disease for clinical management.

Summary:

  • Neuropathologic and genetic findings are driving new classifications within dementia, including Lewy Body Dementia and Frontal Lobe Dementia.
  • Vascular dementia diagnosis now relies on neuroimaging (CT/MRI) rather than the Hachinski Ischemic Score.
  • The amyloid cascade hypothesis is presented as a unifying and promising framework for both early- and late-onset Alzheimer's disease, supporting targeted therapy development.

Impact:

  • Improved diagnostic accuracy and classification of dementia subtypes.
  • Potential for developing specific therapies targeting the amyloid cascade in Alzheimer's disease.
  • Enhanced understanding of psychiatric symptoms in dementia, leading to improved therapeutic strategies.