Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement depletion improves neurological function in cerebral ischemia

U S Vasthare1, F C Barone, H M Sarau

  • 1Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA.

Brain Research Bulletin
|April 4, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Report of Leaf Spot and Blight Caused by Ralstonia pickettii on Bird of Paradise Tree in Italy.

Plant disease·2019
Same author

Pipeline-assisted coiling versus pipeline in flow diversion treatment of intracranial aneurysms.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2018
Same author

Pipeline Embolization Device in the Treatment of Recurrent Previously Stented Cerebral Aneurysms.

AJNR. American journal of neuroradiology·2015
Same author

Spontaneous delayed migration/shortening of the pipeline embolization device: report of 5 cases.

AJNR. American journal of neuroradiology·2013
Same author

Stent-assisted coiling versus balloon remodeling of wide-neck aneurysms: comparison of angiographic outcomes.

AJNR. American journal of neuroradiology·2013
Same author

Intracranial vertebral artery dissections: evolving perspectives.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2012

Depleting the complement system significantly improved blood flow and neurological outcomes in rats after cerebral ischemia and reperfusion injury. This suggests the complement system exacerbates brain damage during these events.

Area of Science:

  • Neuroscience
  • Immunology
  • Cardiovascular Research

Background:

  • Cerebral ischemia/reperfusion (I/R) injury is a major cause of brain damage.
  • The complement system, a part of innate immunity, is implicated in inflammatory processes and tissue damage.

Purpose of the Study:

  • To investigate the role of the complement system in exacerbating cerebral I/R injury.
  • To determine if complement depletion improves outcomes following cerebral I/R.

Main Methods:

  • Compared rats with normal complement levels to those depleted of complement using cobra venom factor (CVF).
  • Assessed reactive hyperemia, somatosensory evoked potentials (SSEPs), and leukocyte infiltration (myeloperoxidase and Leukotriene B4 activity).

Main Results:

Related Experiment Videos

  • Complement-depleted rats showed significantly greater reactive hyperemia.
  • Better preservation of SSEPs was observed in complement-depleted animals.
  • No significant differences in leukocyte infiltration were found between groups.

Conclusions:

  • Complement system activation contributes to the exacerbation of cerebral I/R injury.
  • Complement depletion improves cerebral blood flow and neurological outcomes after I/R.
  • The protective effects are independent of changes in leukocyte infiltration.