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Activation of blood coagulation in patients with mitral stenosis and sinus rhythm
M Ileri1, Y Büyükaşik, N S Ileri
1Department of Hematology, Hacettepe University Medical School, Ankara, Turkey.
Insights
Patients with mitral stenosis (MS) and sinus rhythm (SR) show increased blood coagulation when left atrial spontaneous echo contrast (LASEC) is present. LASEC indicates a hypercoagulable state in these patients.
Area of Science:
- Cardiology
- Hematology
- Medical Imaging
Background:
- Mitral stenosis (MS) is a condition affecting heart valve function.
- The relationship between MS, sinus rhythm (SR), and blood coagulation activation is not fully understood.
- Left atrial spontaneous echo contrast (LASEC) is an echocardiographic finding that may indicate altered blood flow dynamics.
Purpose of the Study:
- To determine if blood coagulation is activated in patients with MS and SR.
- To evaluate the predictive value of LASEC for heightened coagulation activity in MS patients.
- To investigate the presence of a hypercoagulable state in MS with SR.
Main Methods:
- Assessed patients with mitral stenosis (MS) and sinus rhythm (SR).
- Measured in vivo hemostatic markers, including thrombin-antithrombin III complexes and prothrombin fragment 1+2.
- Utilized echocardiography to identify left atrial spontaneous echo contrast (LASEC).
Main Results:
- Patients with MS and SR exhibited evidence of blood coagulation activation.
- The presence of LASEC was associated with increased coagulation activity.
- A hypercoagulable state was identified in MS patients with SR when LASEC was observed.
Conclusions:
- Blood coagulation activation occurs in patients with mitral stenosis and sinus rhythm.
- Left atrial spontaneous echo contrast (LASEC) serves as a valuable predictor of increased coagulation activity in this population.
- LASEC presence signifies a hypercoagulable state in MS patients with SR, highlighting potential thrombotic risks.
Abstract:
The aim of this study was to assess whether there is blood coagulation activation in patients with mitral stenosis (MS) and sinus rhythm (SR) and to investigate the value of left atrial spontaneous echo contrast (LASEC) as a predictive sign of increased coagulation activity. Using thrombin-antithrombin III complexes and prothrombin fragment 1+2 as in vivo hemostatic markers, we concluded that there is a hypercoagulable state in patients with MS and SR when LASEC is present.