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Multilobular osteochondrosarcoma in 39 dogs: 1979-1993
W S Dernell1, R C Straw, M F Cooper
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
Journal of the American Animal Hospital Association
|April 4, 1998
Summary
Multilobular osteochondrosarcoma (MLO) in older, large-breed dogs often recurs or metastasizes, but aggressive treatment can lead to long-term remission. Prognosis depends on tumor grade, margins, and location.
Area of Science:
- Veterinary Oncology
- Comparative Pathology
- Skeletal Biology
Background:
- Multilobular osteochondrosarcoma (MLO) is a primary bone tumor affecting the skull in dogs.
- Older, large-breed dogs are predisposed to MLO, which typically presents as a fixed cranial mass.
Purpose of the Study:
- To evaluate treatment outcomes and prognostic factors for dogs with multilobular osteochondrosarcoma.
- To determine recurrence rates, metastasis incidence, and survival times following various treatment modalities.
Main Methods:
- Retrospective study of 39 dogs with MLO, analyzing treatment (surgery alone, adjuvant therapy, no treatment) and outcomes.
- Assessment of histological grade, surgical margins, and tumor location as prognostic indicators.
Main Results:
- 47% of treated dogs experienced local tumor recurrence; 56% developed metastasis.
- Median times to recurrence, metastasis, and survival were 797, 542, and 797 days, respectively.
- Histological grade, surgical margins, and tumor location significantly impacted patient outcomes.
Conclusions:
- MLO is locally invasive and moderately metastatic, necessitating aggressive treatment strategies.
- Long-term remission is achievable with prompt and thorough intervention, despite the tumor's aggressive nature.