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Molecular cloning and functional expression of a rabbit renal organic cation transporter
S Terashita1, M J Dresser, L Zhang
1Department of Biopharmaceutical Sciences, University of California, San Francisco 94143, USA.
Biochimica Et Biophysica Acta
|April 7, 1998
Abstract:
A cDNA encoding an organic cation transporter (rbOCT1) was isolated from rabbit kidney. The cDNA encodes a 554 amino acid protein that is highly homologous to other mammalian organic cation transporters. rbOCT1 mediated 3H-1-methyl-4-phenylpyridinium (3H-MPP+) transport in Xenopus laevis oocytes was saturable, sensitive to membrane potential, and inhibited by various organic cations. rbOCT1 mRNA transcripts are expressed in the kidney, liver, and intestine.