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A 75-kD autoantigen recognized by sera from patients with X-linked autoimmune enteropathy associated with nephropathy
I Kobayashi1, K Imamura, M Yamada
1Department of Paediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
Abstract:
Autoimmune enteropathy (AIE) is a rare disorder characterized by intractable diarrhoea and antienterocyte autoantibody. In this study, we detected a 75-kD autoantigen which distributed through the whole intestine and the kidney, as assessed by Western blot analysis using sera from two unrelated cases of AIE associated with nephropathy. Our results suggest that the detection of the autoantibody against the 75-kD antigen has a diagnostic value in AIE and that the autoimmune reaction against the 75-kD antigen may be implicated in the development of intestinal and renal tissue damage in this rare disorder.
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