Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histological classification of chronic hepatitis

V J Desmet1

  • 1K.U.Leuven, Department of Pathology, Belgium.

Acta Gastro-Enterologica Belgica
|April 8, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comments on cirrhosis reversal.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2005
Same author

Histopathology of chronic cholestasis and adult ductopenic syndrome.

Clinics in liver disease·2004
Same author

Reversal of cirrhosis: evidence-based medicine?

Gastroenterology·2003
Same author

Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors.

Hepatology (Baltimore, Md.)·2000
Same author

International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis.

Journal of hepatology·1999
Same author

Expression of cytokeratin 20 in developing rat liver and in experimental models of ductular and oval cell proliferation.

Journal of hepatology·1998
Same journal

Silent Fungus, Sudden Crisis: Gastrointestinal Bleeding due to Disseminated Histoplasmosis.

Acta gastro-enterologica Belgica·2026
Same journal

Acute oesophageal necrosis following ethyl-induced emesis: A Case Report.

Acta gastro-enterologica Belgica·2026
Same journal

Conservative Management of Omental Infarction Using Only Analgesia.

Acta gastro-enterologica Belgica·2026
Same journal

Angor abdominalis caused by a pancreatic arteriovenous malformation: a case report.

Acta gastro-enterologica Belgica·2026
Same journal

Gastric Trichobezoars in Children and Adolescents: A Single-Center Case Series.

Acta gastro-enterologica Belgica·2026
Same journal

Therapeutic challenges in the multidisciplinary approach of liver transplant-associated biliary tract complications in Roux-en-Y gastric bypass patients.

Acta gastro-enterologica Belgica·2026
See all related articles

The 1968 chronic hepatitis classification is outdated due to newly discovered causes like viruses and drugs. A 1994 proposal emphasizes etiology, grading, and staging for better treatment.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Virology

Background:

  • The 1968 chronic hepatitis classification distinguished stages and activity (persistent vs. aggressive), suitable when etiology was unknown and presumed autoimmune.
  • Immunosuppressive therapy was reserved for severe cases, validating the classification's utility at the time.

Purpose of the Study:

  • To address the need for an updated chronic hepatitis classification following the discovery of diverse etiologies (hepatitis viruses B, D, C, G, drug toxicity, autoimmune hepatitis).
  • To introduce the 1994 proposals from the International Association for the Study of the Liver and World Congresses of Gastroenterology for a new classification system.

Main Methods:

  • The proposed classification emphasizes primary categorization by etiology.
  • It incorporates determination of disease severity (grading) and stage of progression (staging).

Related Experiment Videos

  • Availability of semiquantitative scoring systems for histological grading and staging of liver biopsies is noted.

    • Main Results:

    • The 1994 proposals aimed to align classification with the need for divergent therapeutic approaches based on etiology.
    • Semiquantitative scoring systems are valuable for evaluating new treatment regimens and comparing pre- and post-treatment biopsies.
    • Routine reporting of liver biopsies does not require semiquantitative scoring.

    Conclusions:

    • The evolution of chronic hepatitis understanding necessitates a classification system that accounts for diverse etiologies.
    • Etiology-based classification, coupled with grading and staging, is crucial for guiding appropriate therapeutic strategies.
    • While semiquantitative scoring aids research and treatment evaluation, it is not standard for routine biopsy reporting.