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Kappa-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab
R Freudenthal1, F Locatelli, G Hermitte
1Facultad de Ciencias Exactas y Naturales, Departamento de Ciencias Biológicas, Universidad de Buenos Aires, Argentina.
Abstract:
Regulation of gene expression has been involved in long-term memory consolidation. Present results support the role of Rel/ NFkappa-B like activation in this process. In the crab Chasmagnathus, the spaced presentation of 15 or more danger stimuli induces long-term habituation (LTH), while no LTH is observed after a massed training of 600 trials. When a group trained with 30 spaced trials was compared with a passive control group and massed trained groups, a higher level of specific Rel/kappa-B like DNA-binding activity was found in brain nuclear extracts. These results strongly suggest that the enhancement of Rel/kappa-B like DNA-binding activity in the brain is specifically related to LTH formation.