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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
A model of disease and vaccination for infections with acute and chronic phases
1Department of Mathematical Sciences, The University of Liverpool, Liverpool, L69 3BX.
Abstract:
A general model is presented of a disease in which both recovered and vaccinated individuals are protected from acute disease, but are still susceptible to chronic infection. The special threshold conditions for the establishment and persistence of such a disease are derived and explained in full. The efficacies of alternative vaccination strategies are detailed and a specific example of such a disease is given by examining feline calicivirus (FCV), a cause of upper respiratory tract disease in cats.
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