A flow model of cerebral aneurysms for use with power Doppler studies

It has recently been observed using power Doppler that cerebral aneurysms appear to change size through the cardiac cycle. The purpose of this study was to develop a pulsatile flow model of cerebral aneurysm expansion and to investigate whether the observations of pulsation could be confirmed using the model. The model consisted of a latex bubble glued onto the side of a latex tube. A computer controlled pump was used to generate pulsatile flow. The degree of bubble expansion was adjusted by the use of flow restrictor placed in the downstream section of the flow rig. Ultrasound images were acquired using an Acuson 128 XP/10V colour flow scanner. True expansion (maximum area/minimum area) was measured from the B-scan image using a 7 MHz probe. Three observers measured expansion of the simulated aneurysm from the power Doppler images using a 2 MHz probe. Expansion measured with the power Doppler decreased as the colour gain setting increased, and decreased as the persistence increased. The true expansion of 1.43 was comparable with the colour gain set optimally for a persistence value of 3. The model allows simple investigations of the relationship between true aneurysm expansion and that measured from the power Doppler images. Colour gain and persistence settings must be standardized in clinical studies.