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Neoplastic odontogenic epithelial cells express bone sialoprotein
J Chen1, T B Aufdemorte, H Jiang
1Department of Pediatric Dentistry, The University of Texas Health Science Center at San Antonio, 78284, USA.
The Histochemical Journal
|April 16, 1998
Summary
Bone sialoprotein (BSP) is crucial for mineralization and is expressed in odontogenic tumors. This study found BSP in neoplastic cells, suggesting its role in pathological calcification during tumor development.
Area of Science:
- Oral pathology
- Biochemistry
- Oncology
Background:
- Bone sialoprotein (BSP) is a key matrix protein involved in bone, dentin, and cementum formation and mineralization.
- Its role in odontogenic neoplasms, particularly pathological calcification, is not fully understood.
Purpose of the Study:
- To investigate the expression and localization of Bone sialoprotein (BSP) in various odontogenic tumors.
- To determine the potential role of BSP in the neoplastic process and pathological calcification within these tumors.
Main Methods:
- Histological analysis of odontogenic neoplasms.
- Immunohistochemistry using human BSP antibodies.
- In situ hybridization for BSP mRNA detection.
Main Results:
- BSP mRNA and protein were detected in neoplastic epithelial cells of ameloblastoma.
- BSP immunoreactivity was observed in calcified masses and surrounding cells in calcifying epithelial odontogenic tumor.
- Strong BSP signals were found in cells near calcifying ghost cells in calcifying odontogenic cysts.
Conclusions:
- Active expression of BSP in epithelial cells of odontogenic tumors indicates gene activation during neoplastic processes.
- BSP likely plays a significant role in tumor formation, differentiation, and pathological calcification in these conditions.