Cellular expression of the cytolytic factor in earthworms Eisenia foetida
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Published on: October 18, 2017
M Bilej1, P Rossmann, M Sinkora
1Department of Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídenská, Prague.
Abstract:
Coelomic fluid of earthworms contains a 42 kDa protein designated CCF-1 (coelomic cytolytic factor 1), which accounts for approximately 40% of cytolytic activity of the entire coelomic fluid. CCF-1 was documented to be present on cells of the mesenchymal lining of the coelomic cavity as well as on free coelomocytes. Both cellular and humoral levels of CCF-1 were significantly increased after parenteral injection of endotoxin. Moreover, CCF-1 seems to be involved in cell mediated cytotoxicity, because cytotoxic activity is blocked in the presence of anti-CCF-1 monoclonal antibody (mAb).
