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Nothramicin, a new anthracycline antibiotic from Nocardia sp. MJ896-43F17
I Momose1, N Kinoshita, R Sawa
1Institute of Microbial Chemistry, Tokyo, Japan.
The Journal of Antibiotics
|April 17, 1998
Abstract:
A new antibiotic designated nothramicin was isolated from the culture broth of Nocardia sp. MJ896-43F17 which was closely related to Nocardia brasiliensis. It was isolated by the Diaion HP-20 column chromatography, butyl acetate extraction and purified by HPLC. It inhibited the growth of mycobacteria at the concentration of 1.56 approximately 25 microg/ml. Nothramicin was revealed to be a new member of anthracycline antibiotics by the various spectroscopies.