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Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers

K Becker1, S N Savvides, M Keese

  • 1Biochemistry Center, University of Heidelberg, Germany. katja.becker@urz.uni-heidelberg.de

Nature Structural Biology
|April 18, 1998
PubMed
Summary

Nitric oxide (NO) inactivates human glutathione reductase (hGR) by oxidizing cysteine residues. Different NO carriers cause distinct chemical modifications, revealing sulfhydryl oxidation as a key NO mechanism.

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