Related Experiment Videos
Hereditary non-polyposis colorectal cancer
S E Green1, D M Bradburn, J S Varma
1Department of Surgery, University of Newcastle Upon Tyne, UK.
International Journal of Colorectal Disease
|April 21, 1998
Summary
Hereditary non-polyposis colorectal cancer (HNPCC) is a genetic condition causing early-onset cancers. Advances in molecular genetics identified four key genes, but management and screening remain debated, especially regarding predictive testing.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome.
- Affected individuals have an increased risk of early-onset colorectal and extracolonic cancers, particularly endometrial cancer.
Purpose of the Study:
- To describe the genetic basis and pathological features of HNPCC.
- To discuss current controversies in HNPCC management, screening, and predictive testing.
Main Methods:
- Review of molecular genetics advances in HNPCC.
- Analysis of pathological features and clinical presentation.
- Discussion of current management and screening controversies.
Main Results:
- Identification and sequencing of four major genes implicated in HNPCC.
- Description of disease characteristics and genetic underpinnings.
- Highlighting the lack of established management and screening protocols.
Conclusions:
- Predictive testing for HNPCC presents ethical and clinical challenges.
- Further research is needed to establish clear guidelines for HNPCC management and screening.