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Interaction between menstrual cyclicity and gonadotropin pulsatility
M Filicori1, C Tabarelli, P Casadio
1Reproductive Endocrinology Center, University of Bologna, Italy. filicori@almadns.unibo.it
Hormone Research
|April 29, 1998
Summary
Pulsatile luteinizing hormone (LH) secretion is vital for the menstrual cycle. Abnormal LH patterns are linked to menstrual disorders, highlighting its regulatory role.
Area of Science:
- Reproductive Endocrinology
- Neuroendocrinology
Background:
- Pulsatile gonadotropin secretion regulates the normal menstrual cycle.
- Luteinizing hormone (LH) secretion exhibits dynamic changes throughout the menstrual cycle.
- Disruptions in pulsatile LH secretion are implicated in most menstrual disorders.
Purpose of the Study:
- To summarize key features of pulsatile LH secretion.
- To describe LH secretion in normal menstrual cycles.
- To detail LH secretion patterns in ovulatory disorders.
Main Methods:
- Literature review of studies on pulsatile LH secretion.
- Analysis of hormonal profiles during the menstrual cycle.
- Comparison of LH secretion in healthy and disordered cycles.
Main Results:
- Pulsatile LH secretion follows distinct patterns in the normal menstrual cycle.
- Specific alterations in LH pulsatility are observed in various ovulatory disorders.
- These changes underscore the role of LH in reproductive health.
Conclusions:
- Pulsatile LH secretion is a critical regulator of the menstrual cycle.
- Understanding LH secretion dynamics is essential for diagnosing and managing menstrual disorders.
- Further research into LH pulsatility may reveal new therapeutic targets.