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Related Experiment Videos

Clinical experience with cyanoacrylate tissue adhesive

M Moschos1, D Droutsas, P Boussalis

  • 1Department of Ophthalmology, University of Athens, Greece.

Documenta Ophthalmologica. Advances in Ophthalmology
|January 1, 1996
PubMed
Summary

Cyanoacrylate tissue adhesive is a safe and effective method for healing corneal perforations, even in severe cases. This technique successfully avoided enucleation in 385 patients, with minimal complications like ocular hypotony and infection.

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Area of Science:

  • Ophthalmology
  • Biomaterials Science

Background:

  • Corneal perforations pose significant risks, often necessitating complex surgical interventions.
  • Traditional treatments for corneal wounds can be associated with considerable complications.

Purpose of the Study:

  • To investigate the indications, outcomes, and complications of using cyanoacrylate tissue adhesive in managing corneal perforations.
  • To evaluate the efficacy of cyanoacrylate adhesive as a conservative treatment for corneal wounds.

Main Methods:

  • A retrospective study of 385 cases treated with cyanoacrylate tissue adhesive between 1980 and 1995.
  • In cases of large perforations (>3 mm), a nylon suture reticulum was created before adhesive application.
  • Early application of bandage contact lenses and topical antibiotics was employed post-procedure.

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Main Results:

  • Only three cases of ocular hypotony and two of microbial infection were reported among 385 patients.
  • Enucleation was avoided even in severe cases involving large corneal perforations and ocular infection.
  • The combined approach of adhesive, bandage contact lens, and antibiotics resulted in a low infection incidence.

Conclusions:

  • Cyanoacrylate tissue adhesive provides a safe and effective technique for healing corneal wounds.
  • This method offers a viable alternative to tectonic penetrating keratoplasty, reducing associated risks.
  • The study demonstrates encouraging outcomes for managing corneal perforations with cyanoacrylate adhesive.