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Related Experiment Videos

Intellectual decline after stroke: the Framingham Study

C S Kase1, P A Wolf, M Kelly-Hayes

  • 1Department of Neurology, Boston University School of Medicine, Mass 02118, USA. cskase@bu.edu

Stroke
|April 29, 1998
PubMed
Summary
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Cognitive decline after stroke is significant, with intellectual impairment independent of depression. Large, left-sided strokes on CT scans correlate with this decline.

Area of Science:

  • Neurology
  • Cognitive Science
  • Epidemiology

Background:

  • Cognitive decline post-stroke is poorly understood due to lack of prestroke cognitive data.
  • Previous studies often focused on dementia diagnosis rather than precise cognitive changes.

Purpose of the Study:

  • To define the causes and characteristics of cognitive decline after stroke.
  • To compare poststroke cognitive performance with prestroke baseline measurements.

Main Methods:

  • Utilized the Mini-Mental State Examination (MMSE) to assess cognitive performance in 74 stroke patients and 74 matched controls.
  • Correlated cognitive changes with depression symptoms (CES-D scale) and CT-documented stroke characteristics.

Main Results:

Related Experiment Videos

  • Stroke patients showed a significant decline in MMSE scores poststroke compared to prestroke baseline and controls.
  • Poststroke cognitive decline correlated with large, left-sided strokes on CT scans.
  • Higher depression scores were observed in stroke patients, but cognitive decline was independent of depression.

    • Conclusions:

    • Stroke leads to a significant decline in cognitive performance when prestroke and poststroke measures are compared.
    • The observed intellectual decline in stroke patients appears unrelated to the presence of depression.