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[Arthritis caused by use of rifabutine++ in Mycobacterium avium infection]
J C van Denderen1, E A Mensen, A M Vints
1Jan van Breemen Instituut, Amsterdam.
Nederlands Tijdschrift Voor Geneeskunde
|April 29, 1998
Abstract:
A 60-year-old HIV-seronegative man with a Mycobacterium avium pulmonary infection was treated with rifabutin, ethambutol and clarithromycin. He developed a serious arthritis which disappeared after interruption of the medication and recurred after resumption. The arthritis was attributed to the use of rifabutin. This adverse effect is more frequent with higher doses and in combination with the use of macrolide antibiotics.