Developmental perspectives on epilepsy

This paper reviews current knowledge about epileptogenesis in the developing brain. Animal studies indicate that the maturational balance of excitatory and inhibitory neurotransmitter systems should result in an increased susceptibility to seizures. However, the reason for specific age-locked syndromes and the high rate of impairments secondary to early onset epilepsy remain mysterious. Present research activity is directed to prevention and amelioration of these severe cognitive and psychiatric impairments.