Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Checkpoints in the cell cycle from a modeler's perspective

J J Tyson1, B Novak, K Chen

  • 1Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061-0406, USA.

Progress in Cell Cycle Research
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Further correspondence.

Microbiology (Reading, England)·2021
Same author

The influence of mouth breathing on skeletal and dental features of splanchnocranium.

Bratislavske lekarske listy·2021
Same author

Do we have to reduce the recall period? Validity of a daily physical activity questionnaire (PAQ24) in young active adults.

BMC public health·2020
Same author

Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

The influence of different illumination parameters on protoporphyrin IX induced cell death in squamous cell carcinoma cells.

Photodiagnosis and photodynamic therapy·2018
Same author

Patient-reported health outcomes in patients with non-melanoma skin cancer and actinic keratosis: results from a large-scale observational study analysing effects of diagnoses and disease progression.

Journal of the European Academy of Dermatology and Venereology : JEADV·2017
Same journal

Cytometry of cell cycle regulatory proteins.

Progress in cell cycle research·2003
Same journal

Selective protection of normal proliferating cells against the toxic effects of chemotherapeutic agents.

Progress in cell cycle research·2003
Same journal

The actin cytoskeleton as a therapeutic target: state of the art and future directions.

Progress in cell cycle research·2003
Same journal

Roles and regulation of serine/threonine-specific protein phosphatases in the cell cycle.

Progress in cell cycle research·2003
Same journal

The interaction of glycogen synthase kinase-3 (GSK-3) with the cell cycle.

Progress in cell cycle research·2003
Same journal

The peptidyl-prolyl isomerase Pin1.

Progress in cell cycle research·2003
See all related articles

This study uses mathematical models to explore cell cycle checkpoints, specifically the G1 ("Start") and G2 phases. The research connects molecular mechanisms to the physiological behaviors of cell cycle arrest.

Area of Science:

  • Cell Biology
  • Mathematical Modeling
  • Biophysics

Background:

  • The cell division cycle is essential for growth and reproduction.
  • Cell cycle checkpoints prevent errors during DNA replication.
  • Checkpoints regulate progression based on internal and external cues.

Purpose of the Study:

  • To investigate cell cycle arrest using mathematical models.
  • To analyze checkpoint control in G1 ("Start") and G2 phases.
  • To link molecular mechanisms with physiological cell cycle properties.

Main Methods:

  • Development of simple mathematical models.
  • Simulation of cell cycle dynamics.
  • Analysis of checkpoint functions in G1 and G2.

Related Experiment Videos

Main Results:

  • Models demonstrate how checkpoints regulate cell cycle progression.
  • Mathematical framework established to study cell cycle arrest.
  • Insights into the relationship between molecular events and cell cycle outcomes.

Conclusions:

  • Mathematical modeling provides a valuable tool for understanding cell cycle regulation.
  • The study elucidates the role of checkpoints in maintaining genomic stability.
  • Findings contribute to a deeper comprehension of cell division control.