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Related Experiment Videos

Cyclin A: function and expression during cell proliferation

C Desdouets1, J Sobczak-Thépot, M Murphy

  • 1INSERM U370, Paris, France.

Progress in Cell Cycle Research
|January 1, 1995
PubMed
Summary

Cyclin A regulates cell cycle progression through S phase and the G2/M transition. This review explores cyclin A

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Cyclin A is a critical regulatory protein in mammalian cell cycle progression.
  • Cyclin A associates with distinct cyclin-dependent kinases (cdks) to control cell cycle phases.
  • Evidence links cyclin A to the development of human cancers.

Purpose of the Study:

  • To review the multifaceted role of cyclin A in cell cycle regulation.
  • To examine the involvement of cyclin A in S phase and the S/G2 transition.
  • To discuss the implications of cyclin A in human carcinogenesis and its gene's transcriptional regulation.

Main Methods:

  • Literature review of existing studies on cyclin A.
  • Analysis of research linking cyclin A to cell cycle phases (S and G2/M).
  • Examination of evidence implicating cyclin A in human cancer development.

Main Results:

  • Cyclin A's dual role in regulating S phase and the G2/M transition is confirmed.
  • Cyclin A's association with specific cdks dictates its function in different cell cycle stages.
  • Significant evidence supports cyclin A's involvement in human carcinogenesis.

Conclusions:

  • Cyclin A is a pivotal regulator of the cell cycle, essential for DNA replication and mitosis.
  • Dysregulation of cyclin A contributes to the pathogenesis of human cancers.
  • Understanding cyclin A's transcriptional regulation is crucial for therapeutic strategies.

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