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Related Experiment Videos

The cyclin C/Cdk8 kinase

V Leclerc1, P Léopold

  • 1URA 671 CNRS, Villefranche-sur-mer, France.

Progress in Cell Cycle Research
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Cyclin C and its partner Cdk8 were identified in a screen for cell cycle genes. This protein complex may regulate RNA polymerase II function in metazoans.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Cyclin C was identified through genetic screening for its ability to complement yeast cell cycle mutations.
  • Unlike other cyclins (D, E), cyclin C's metazoan cell cycle role remained unclear.
  • Cdk8, the catalytic partner of cyclin C, is a novel protein kinase.

Purpose of the Study:

  • To investigate the function of cyclin C and its associated kinase, Cdk8.
  • To explore the potential role of the cyclin C-Cdk8 complex in metazoan gene regulation.

Main Methods:

  • Genetic screening in S. cerevisiae.
  • Protein complex isolation and characterization.
  • Sequence homology analysis.

Main Results:

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  • Cyclin C and Cdk8 form a large multi-protein complex with RNA polymerase II.
  • This complex shares structural and functional similarities with the yeast RNA polymerase II holoenzyme.
  • Sequence similarities suggest a conserved regulatory role.

Conclusions:

  • The cyclin C-Cdk8 complex is implicated in controlling RNA polymerase II function.
  • This finding suggests a conserved mechanism for regulating transcription across species.
  • Further research is warranted to elucidate the precise regulatory role.