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Viruses and the cell cycle

A Op De Beeck1, P Caillet-Fauquet

  • 1Département de Biologie Moléculaire, Université Libre de Bruxelles, Belgium.

Progress in Cell Cycle Research
|January 1, 1997
PubMed
Summary

Viruses manipulate host cell cycles to replicate. This review details viral strategies for controlling cell cycle regulators to create favorable replication environments.

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Area of Science:

  • Virology
  • Cell Biology
  • Molecular Biology

Background:

  • Viruses rely on host cell machinery for replication and gene expression.
  • Replicating cells offer abundant resources (deoxynucleotides, enzymes) exploited by viruses.
  • Viruses employ diverse strategies to ensure access to these resources.

Purpose of the Study:

  • To review the various strategies viruses use to alter host cell environments.
  • To examine how viruses manipulate cell cycle regulators for their own benefit.
  • To understand the interplay between viral life cycles and host cell processes.

Main Methods:

  • Literature review of viral strategies.
  • Analysis of viral mechanisms impacting host cell cycle.
  • Focus on viruses that modulate cell cycle regulators.

Main Results:

  • Viruses induce quiescent cells into S phase (e.g., adenovirus).
  • Some viruses wait for host cell replication (e.g., parvovirus).
  • Viruses can maintain favorable cell cycle phases (e.g., Epstein-Barr virus) or inhibit apoptosis (e.g., human cytomegalovirus).

Conclusions:

  • Viruses actively modify host cell cycle regulation to optimize viral replication.
  • Understanding these viral strategies provides insights into host-pathogen interactions.
  • Targeting viral manipulation of cell cycle regulators could offer therapeutic avenues.

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