An evaluation of the clinical pathologic findings in experimentally induced urinary bladder rupture in pre-ruminant...

The purpose of this project was to study the biochemical abnormalities that develop over time in preruminant calves with experimentally induced uroperitoneum. Uroperitoneum was produced by incising the bladder via a standing left flank laparotomy. Serum and peritoneal concentrations sodium, chloride, potassium, phosphate and creatinine were determined at 0, 2, 4, 8, 24, and 40 h. Serum creatinine concentration was increased by 8 h post-bladder rupture. Peritoneal concentrations of potassium and phosphate were significantly elevated 2 h after bladder rupture and peritoneal creatinine was significantly elevated by 4 h. Serum to peritoneal fluid ratios for potassium, phosphate and creatinine exceeded 2:1 within 2 h of bladder rupture. Pre-ruminant calves with experimentally induced uroperitoneum did not become hyperkalemic during the 40 h experiment.