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A report of pediatric SUCCIMER overdose
1Illinois Poison Center, Chicago 60661, USA.
Veterinary and Human Toxicology
|April 29, 1998
Summary
Succimer, a chelating agent, was administered to a child at a high dose of 185 mg/kg for dimercapto-succinic acid. The treatment was well-tolerated, with no adverse effects observed in the pediatric patient.
Area of Science:
- Pediatric Toxicology
- Pharmacology
- Chelation Therapy
Background:
- Dimercaptosuccinic acid (DMSA), also known as succimer, is a chelating agent used in heavy metal poisoning treatment.
- Pediatric dosing and safety profiles for chelating agents require thorough investigation.
Observation:
- A 3-year-old child received succimer capsules.
- The administered dose was 185 mg of dimercaptosuccinic acid per kilogram of body weight.
Findings:
- The high-dose administration of succimer in a pediatric patient resulted in no observable adverse effects.
- This suggests a potential safety margin for dimercaptosuccinic acid at this dosage in children.
Implications:
- The findings support the safety of high-dose succimer (dimercaptosuccinic acid) in pediatric cases.
- Further research into DMSA pharmacokinetics and safety in children is warranted for optimizing treatment protocols.