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Biological response modifiers: interferons, interleukins, recombinant products, liposomal products
1Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada.
Summary
Cytokines, such as interferons and interleukins, show promise for treating infections and cancers in pets. New delivery methods may improve their effectiveness and safety for veterinary use.
Area of Science:
- Veterinary Medicine
- Immunology
- Pharmacology
Background:
- Enhancing immune responses against infections and neoplasms has long been a goal.
- Cytokines are increasingly recognized for their potential therapeutic applications.
Purpose of the Study:
- To review the potential clinical applications of cytokines in companion animals.
- To discuss challenges and innovative delivery methods for cytokine therapy in veterinary medicine.
Main Methods:
- Literature review of cytokine therapy in human and veterinary medicine.
- Discussion of specific cytokines like interferons, interleukins, and erythropoietin.
- Exploration of novel drug delivery systems for cytokines.
Main Results:
- Cytokines like interferons and interleukins may benefit pets with chronic viral infections and cancers.
- Erythropoietin is useful for chronic renal failure.
- Current recombinant human products are expensive and not licensed for veterinary use.
Conclusions:
- Cytokine therapy holds significant potential for treating fatal disorders in dogs and cats.
- Innovative delivery methods (liposomes, gene therapy, oral administration) could enhance therapeutic index and reduce side effects.
- Veterinarians should monitor advancements in biological response modification and cytokine delivery systems.