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Calciphylaxis: a cause of necrotic ulcers in renal failure
A N Kalaaji1, M C Douglass, M Chaffins
1Department of Dermatology Henry Ford Hospital, Detroit, Michigan 48202, USA.
Background:
Calciphylaxis is a rare and life-threatening condition occurring in patients with end-stage renal disease on dialysis. The diagnosis is frequently delayed or missed and therapy is often unsuccessful.
Objective:
The clinical and pathological components of calciphylaxis are emphasized in a patient that may facilitate early diagnosis and initiation of therapy.
Results:
Early recognition of the clinical signs and symptoms of calciphylaxis is crucial. The tissue diagnosis requires large elliptical biopsies because histological findings are segmental and often missed.
Conclusion:
Early diagnosis and intervention in calciphylaxis is critical. Parathyroidectomy should be considered in all cases.