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Unexpected electrophoretic migration of RNA with different 3' termini causes a RNA sizing ambiguity that can be
J Cruz-Reyes1, K J Piller, L N Rusché
1Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Biochemistry
|May 23, 1998
Abstract:
It has been widely believed that the electrophoretic migration difference of otherwise identical RNAs with a P versus OH terminus would be the same as occurs for DNA, a fairly reproducible approximately 1/2 nucleotide (nt) offset. RNA with a 5'-OH indeed migrates