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Genetic analysis of hydroxymethylglutaryl-coenzyme A reductase regulated degradation
1UCSD Department of Biology 0347, La Jolla 92093, USA. rhampton@biomall.ucsd.edu
Current Opinion in Lipidology
|April 29, 1998
Abstract:
Hydroxymethylglutaryl-coenzyme A reductase degradation occurs in the endoplasmic reticulum, and is regulated by the mevalonate pathway. In order to discover the molecules that mediate the degradation process and its control, we conducted a genetic analysis of the degradation of the yeast Hmg2p isozyme of hydroxymethylglutaryl-coenzyme A reductase. Hmg2p degradation occurs by the action of HRD genes that direct Hmg2p to the ubiquitin-proteasome pathway. Regulation of HRD-dependent Hmg2p degradation appears to occur by the action of a separate set of CRD genes.