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Related Experiment Video

Updated: Jul 11, 2026

Preparation of the Rat Vocal Fold for Neuromuscular Analyses

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Published on: May 15, 2020

Edema formation in the rat larynx

M Lidegran¹, S Domeij, B Carlsöö

¹Department of Otorhinolaryngology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.

Cell and Tissue Research

|June 2, 1998

Summary

Compound 48/80 triggers mast cell degranulation and laryngeal edema in rats. Substance P and capsaicin increase vascular permeability via a different mechanism, distinct from mast cell activation.

Area of Science:

Laryngology
Cell Biology
Pharmacology

Background:

Mast cells play a crucial role in inflammatory responses within the larynx.
Understanding the mechanisms of laryngeal edema is vital for treating airway inflammation.

Purpose of the Study:

To investigate the effects of compound 48/80, substance P, and capsaicin on laryngeal plasma exudation and edema formation in rats.
To differentiate the mechanisms of action of these agents on mast cells and vascular permeability.

Main Methods:

Light and electron microscopy were used to examine laryngeal tissues.
Rats received intravenous injections of compound 48/80, substance P, or capsaicin.
Morphological changes in connective tissue mast cells and laryngeal tissues were analyzed.

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Main Results:

Compound 48/80 induced mast cell degranulation and significant edema in the subglottic region and epiglottis.
Substance P and capsaicin caused plasma exudation and widened intercellular spaces but did not degranulate mast cells.
Edema induced by compound 48/80 was attributed to histamine and serotonin release from mast cells.

Conclusions:

Compound 48/80 exerts its effects through mast cell degranulation and mediator release.
Substance P and capsaicin increase vascular permeability via a direct action on blood vessels, independent of mast cell degranulation.