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Updated: Jul 13, 2026

A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
An abrupt zero-preoxygenation altitude threshold for decompression sickness symptoms
J T Webb1, A A Pilmanis, R B O'Connor
1KRUG Life Sciences Inc., San Antonio, TX 78214, USA.
This study determined the altitude threshold for decompression sickness (DCS) symptoms, finding a 5% incidence at 20,500 ft. This suggests current aerospace altitude exposure guidelines may need revision for enhanced safety.
Area of Science:
- Aerospace Medicine
- Physiology
- Environmental Health
Background:
- Decompression sickness (DCS) symptom thresholds vary widely, from 18,000 to over 25,000 ft.
- Precise DCS threshold determination is crucial for aerospace operational safety and efficiency.
Purpose of the Study:
- To establish a more accurate altitude threshold for the onset of DCS symptoms.
- To evaluate the relationship between simulated altitude exposure and DCS incidence.
Main Methods:
- 124 male subjects were exposed to simulated altitudes ranging from 11,500 ft to 25,000 ft for 4-8 hours, breathing 100% oxygen.
- Monitoring included precordial venous gas emboli (VGE) and DCS symptoms.
- Probit analysis was used to estimate the risk of DCS and VGE at different altitudes.
Main Results:
- Venous gas emboli (VGE) were detected starting at 15,000 ft, with incidence increasing significantly at higher altitudes.
- A 5% incidence of DCS symptoms was observed at 21,200 ft.
- DCS incidence sharply rose to 55% at 22,500 ft.
Conclusions:
- The study concluded a 5% DCS symptom threshold at 20,500 ft under the tested conditions.
- The rapid increase in DCS symptoms above 21,200 ft necessitates a review of current USAF and FAA altitude exposure guidelines.
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