Antibiotic resistance problems in the critical care unit
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Updated: Oct 30, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
J L Mainardi1, J Carlet, J Acar
1Service de Microbiologie Médicale, Fondation Hôpital Saint-Joseph, Paris, France.
Abstract:
The increased resistance of bacteria to antimicrobial agents poses major therapeutic problems for the treatment of patients hospitalized in critical care units. This article discusses the mechanisms of resistance and the basic rationale for the treatment of infected patients. The authors also discuss methods used to control the dissemination of resistant bacteria from patient to patient, the complex problems of colonization, and the strategies used to delay the emergence of resistance to new antibiotics.
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