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Antibiotic resistance. Control strategies
1Infectious Disease Division, Winthrop-University Hospital, Mineola, New York, USA.
Abstract:
Antibiotic resistance is a worldwide concern. Over the past several decades, antibiotic resistance has increased to many respiratory pathogens as well as aerobic gram-negative bacilli. Recently, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) have become important hospital pathogens. Antibiotic resistance is not related to a particular antibiotic structure and is not dependent upon mechanism of antibiotic action. The volume of use per se does not increase antimicrobial resistance. This article discusses control strategies and identifies which antibiotics are associated with the emergence of resistant organisms.
Insights
Antibiotic resistance is a growing global problem, with increasing rates in respiratory pathogens and hospital-acquired infections like MRSA and VRE. This review explores control strategies and links specific antibiotic uses to the rise of resistant organisms.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Antibiotic resistance is a significant worldwide health concern.
- Increasing resistance is observed in respiratory pathogens and aerobic gram-negative bacilli.
- Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) are emerging as critical hospital-acquired pathogens.
Purpose of the Study:
- To discuss strategies for controlling the spread of antibiotic resistance.
- To identify specific antibiotics associated with the emergence of resistant organisms.
- To provide an overview of the current landscape of antimicrobial resistance.
Main Methods:
- Literature review of antibiotic resistance trends.
- Analysis of factors contributing to antimicrobial resistance.
- Identification of key pathogens exhibiting resistance.
Main Results:
- Antibiotic resistance patterns are increasing globally.
- Specific hospital-acquired pathogens like MRSA and VRE are of growing concern.
- Resistance is not tied to antibiotic structure or mechanism of action; volume of use alone does not increase resistance.
Conclusions:
- Effective control strategies are crucial to combat rising antibiotic resistance.
- Understanding the relationship between antibiotic use and resistance emergence is key.
- Further research and targeted interventions are needed to manage resistant organisms.