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Related Experiment Videos

Does circumcision alter the periurethral bacterial flora?

S S Wijesinha1, B L Atkins, N E Dudley

  • 1Department of Pediatric Surgery, John Radcliffe Hospital, Oxford, UK.

Pediatric Surgery International
|May 1, 1998
PubMed
Summary
This summary is machine-generated.

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Circumcision in boys significantly reduced harmful bacteria in the periurethral area. This study suggests male circumcision may offer protection against urinary tract infections (UTIs).

Area of Science:

  • Urology
  • Microbiology
  • Pediatric Surgery

Background:

  • The periurethral area can harbor uropathogenic organisms.
  • Ascending urinary tract infections (UTIs) are a concern, particularly in pediatric patients.
  • Circumcision is a surgical procedure with potential implications for microbial colonization.

Purpose of the Study:

  • To investigate the impact of circumcision on periurethral bacterial flora in boys.
  • To assess whether circumcision alters the presence of uropathogens in the periurethral region.
  • To explore the potential protective effect of circumcision against UTIs.

Main Methods:

  • Prospective study involving 25 boys undergoing circumcision for medical reasons.
  • Periurethral bacterial flora specimens collected before and 3 weeks after surgery.

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  • Each boy served as his own control to minimize confounding variables.

    • Main Results:

    • Before circumcision, 52% of boys harbored uropathogenic organisms (e.g., Escherichia coli, Enterococcus spp.).
    • After circumcision, no uropathogens were detected in any of the boys.
    • The periurethral region was colonized by normal skin commensals post-surgery.

    Conclusions:

    • Circumcision appears to eliminate uropathogens from the periurethral area.
    • The procedure may convert a reservoir for infection into a surface colonized by protective skin flora.
    • Findings provide circumstantial evidence that circumcision may confer protection against UTIs in select male patients.