Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

White matter changes with normal aging

C R Guttmann1, F A Jolesz, R Kikinis

  • 1Department of Radiology, Brigham & Women's Hospital, Boston, MA, USA.

Neurology
|May 5, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lessons to Be Learned about Clinical Trials in Preclinical AD from Ongoing Longitudinal Studies.

The journal of prevention of Alzheimer's disease·2017
Same author

'Alzheimer's Progression Score': Development of a Biomarker Summary Outcome for AD Prevention Trials.

The journal of prevention of Alzheimer's disease·2017
Same author

Automatic Segmentation of Breast Carcinomas from DCE-MRI using a Statistical Learning Algorithm.

Proceedings. IEEE International Symposium on Biomedical Imaging·2017
Same author

Entorhinal Cortex: Antemortem Cortical Thickness and Postmortem Neurofibrillary Tangles and Amyloid Pathology.

AJNR. American journal of neuroradiology·2017
Same author

Testing the Efficacy of Contrast-Enhanced Ultrasound in Detecting Transplant Rejection Using a Murine Model of Heart Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway.

Molecular psychiatry·2016
Same journal

Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

Neurology·2026
Same journal

Cost-Effectiveness of Intracranial Aneurysm Screening: A Systematic Review.

Neurology·2026
Same journal

Rare Eating Epilepsy: Co-Occurrence of Focal Cortical Dysplasia and Gray Matter Heterotopia.

Neurology·2026
Same journal

Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.

Neurology·2026
Same journal

Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

Neurology·2026
Same journal

At Death's Door: Cytosolic Dopamine in Patients With Parkinson Disease.

Neurology·2026
See all related articles

Brain aging shows a significant decrease in white matter volume and an increase in cerebrospinal fluid (CSF) volume in older adults. Gray matter volume remained relatively stable, suggesting specific age-related changes in brain composition.

Area of Science:

  • Neuroimaging
  • Gerontology
  • Brain Aging

Background:

  • Brain structure changes with age, impacting cognitive function.
  • Previous studies suggest age-related gray matter and white matter volume loss.
  • Cerebrospinal fluid (CSF) volume typically increases with age.

Purpose of the Study:

  • To quantitatively assess age-related changes in brain tissue compartments using MRI.
  • To investigate the relationship between white matter, gray matter, and CSF volume across the adult lifespan.
  • To compare age-related brain changes in individuals over 59 years old with younger cohorts.

Main Methods:

  • Quantitative magnetic resonance imaging (MRI) was used to measure brain tissue volumes.
  • Seventy-two healthy volunteers aged 18-81 years participated.

Related Experiment Videos

  • Intracranial fractions of white matter, gray matter, and CSF were calculated.

    • Main Results:

    • White matter fraction significantly decreased in individuals over 59 years old.
    • CSF fraction significantly increased with age.
    • Gray matter fraction showed a slight decrease but no significant difference between the youngest and oldest groups.

    Conclusions:

    • Aging is associated with a significant reduction in white matter volume and a corresponding increase in CSF volume.
    • Gray matter volume appears relatively preserved in healthy aging compared to white matter.
    • Findings align with neuropathological evidence of age-related white matter changes.