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[Nitric oxide in respiratory diseases]

M Andresen1, O Díaz, S Troncoso

  • 1Departamento de Medicina Interna y Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Católica de Chile.

Revista Medica De Chile
|August 1, 1997
PubMed
Summary

Nitric oxide shows promise in treating adult respiratory distress syndrome by improving gas exchange. Its therapeutic role in asthma and chronic lung diseases requires further investigation.

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Focus issue: Artificial intelligence in medical physics.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2021

Area of Science:

  • Pulmonary Medicine
  • Critical Care
  • Respiratory Physiology

Context:

  • Nitric oxide (NO) is increasingly recognized for its role in respiratory diseases.
  • Its vasodilatory properties are beneficial in acute respiratory distress syndrome (ARDS).
  • The therapeutic potential in chronic airway diseases remains less understood.

Purpose:

  • To review the metabolism and mechanisms of action of nitric oxide in the respiratory system.
  • To explore the potential clinical applications of nitric oxide in various respiratory conditions.
  • To discuss the adverse effects associated with nitric oxide therapy in respiratory diseases.

Summary:

  • Nitric oxide acts as a selective pulmonary vasodilator, improving gas exchange and reducing shunting in ARDS.
  • While NO has demonstrated bronchodilator effects, its efficacy in asthma and chronic obstructive pulmonary disease (COPD) is not well-established.
  • This review covers NO metabolism, mechanisms, therapeutic uses, and safety profiles in respiratory contexts.

Impact:

  • Highlights the established benefits of nitric oxide in ARDS management.
  • Identifies knowledge gaps regarding NO's utility in chronic respiratory conditions like asthma and COPD.
  • Provides a comprehensive overview for clinicians and researchers on nitric oxide's role in respiratory medicine.

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